Does Melatonin help against cancer?

Melatonin is a hormone your body makes to grow and develop. It also controls your cycle of being asleep and awake. Small amounts of melatonin are found in fruits, nuts, olive oil, and wine. You can also take it as a supplement to help you sleep. Talk with your healthcare provider if you have hormone-sensitive cancer like breast or prostate cancer. Melatonin can change the amount of estrogen in your body and this may worsen your condition. Clinical trials evaluating melatonin as a monotherapy or in combination with other agents and in patients with solid tumors suggest improvements in quality of life and survival time, but melatonin did not improve appetite, weight, or quality of life in cancer patients with cachexia (which is the wasting of the body that it caused by cancer). In studies of postmenopausal breast cancer survivors, in vitro studies demonstrate antiproliferative effects on human breast cancer and melanoma. In endometrial cancer cells, it interferes with estrogen receptor expression.

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