Cannabinoids are the active constituents that mimic endogenous cannabinoids, and their activity is based on a receptor-mediated mechanism. THC exerts psychoactive and pain-relieving effects by acting as a partial agonist of cannabinoid receptors CB1 (predominantly expressed in the central nervous system) and CB2 (associated with the immune system). CB1 and CB2 are activated through inhibition of adenylate-cyclase. The bioavailability of THC varies and depends on how you smoke it. Much of the cannabis (80-90%) is excreted within 5 days about 65% in the stools and 20 % in the urine.
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