Milk thistle is a plant that has red to purple flowers and shiny pale green leaves. with white veins. Milk thistle is commonly used as herbal supplements for liver problems, but study results are mixed. It has estrogenic effects with greater affinity which help to stop cell growth. Even though it is marketed for liver protection, it could actually have negative impact on patients with history of high use of alcohol. Silibinin is an active ingredient of milk thistle. Silibinin stops the cancer growth of one type of liver cancer called hepatocellular carcinoma. Silibinin suppressed the epidermal growth factor receptor (EGFR)- EGFR activity in breast cancer cells. EGFR is a target on the cell which when active can cause cancer cells to divide more rapidly. Silibinin decrease chemotherapy-induced hepatotoxicity in children with acute lymphoblastic leukemia, and cisplatin-induced nephrotoxicity as well as improve capecitabine-induced hand-foot syndrome and radiation therapy-induced mucositis.
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