Indirubin is derived from the Indigo Plant (Isatis Root). In Asia, it is part of combination formulas used in traditional herbal prescriptions to treat some forms of cancer. Indirubin may also decrease inflammation by inhibiting part of the immune response. There is a lack of evidence to support this use. Case reports and initial analyses suggest possible benefits in leukemia, but clinical trials are needed to confirm this information. A small study in patients with head and neck cancer suggest that indirubin, taken as indigowood root powder, may reduce mucosal damage from radiation therapy. Additional studies are needed to confirm this effect.
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