Cancer cells mutate and they gain the ability to release lots of those angiogenic factors, natural fertilizer that tipped the balance in favor of blood vessels invading the cancer. And once those vessels invade the cancer, it can expand and it can invade local tissues. The same vessels that are feeding tumors allow cancer cells to exit into the circulation as metastases and unfortunately, this late stage of cancer is the one at which it’s most likely to be diagnosed when angiogenesis is already turned on and cancer cells are growing like wild.
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